Anti-TRPA1 antibody [Nle]
An antibody raised against transient receptor potential ankyrin 1 (TRPA1); highly expressed in pain-sensing neurons and tissues with a wide range of agonists that induce pain/inflammation.
Catalogue number crb2005722 Antibody Anti-TRPA1 antibody [Nle] Antigen Peptide KLH conjugated synthetic peptide crb1200931 Protein ID UniProtKB - O75762 Aliases Transient receptor potential cation channel subfamily A member 1, Ankyrin-like with transmembrane domains protein 1, ANKTM1, Transformation-sensitive protein p120, Wasabi receptor Cross-Reactivity Human Host Species Rabbit Antibody Type Polyclonal Concentration 2.0 mg/ml Glycine (R1G), 2.0 mg/ml Glycine (R2G) Target TRPA1 Family Transient receptor (TC 1.A.4) family Storage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/thaw cycles.
Transient receptor potential ankyrin 1 (TRPA1) is a receptor-activated non-selective cation channel involved in pain detection. TRPA1 is activated by many structurally unrelated electrophilic and non-electrophilic chemical compounds. Electrophilic ligands activate TRPA1 by interacting with critical N-terminal Cys residues covalently. A cytosolic factor is required to keep TRPA1 in an agonist-sensitive state for activation by irritants such as allylthiocyanate (AITC) from mustard oil or wasabi, cinnamaldehyde, and diallyl disulfide (DADS). TRPA1 has been linked to numerous pain conditions and is a target for anti-inflammatory and analgesic therapies.
Inner ear function is also believed to be linked to TRPA1. TRPA1 acts as a component for the mechanosensitive transduction channel of hair cells in the inner ear, thereby participating in the perception of sounds.