An antibody raised against TORC-2; a serine/threonine kinase that has a function in a diverse array of systems including cell growth and metabolism.
Catalogue number crb2005646 Antibody Anti-TORC-2 antibody Antigen Peptide KLH conjugated synthetic peptide crb1200856e Protein ID Q53ET0 Human CRTC2 Aliases CREB-regulated transcription coactivator 2, CRTC2, Transducer of regulated cAMP response element-binding protein 2, Transducer of CREB protein 2, TORC-2 Cross-Reactivity Human Host Species Rabbit Antibody Type Polyclonal Concentration 1mg/ml DAB048 Target TORC-2 Post-translational Modification Phosphorylated, Methylated
The role of TORC-2 has not been as well characterised as its family member TORC-1. TORC-2 is a complex that acts as a transcriptional coactivator for CREB1 enhancing its interaction with TAF4 leading to specific gene induction such as steroidogenic gene, StAR. TORC-2 is also as a coactivator in several pathways including the SIK/TORC signalling pathway plus the LKB1/AMPK/TORC2 signalling regulating gluconeogenesis. Also, it is a coactivator for TAX activation of the human T-cell leukaemia virus type 1 (HTLV-1) long terminal repeats (LTR). It is a potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells.
Dysregulation of TORCs or the PI3K-AKT-mTOR pathway have been linked to numerous neurological diseases termed mTORopathies. Overactivation of mTOR pathways are a known cause of epilepsy, developmental disability, and autism. Due to the numerous functions being uncovered that are exclusive to TORC-2 and the diseases implicated this antibody could be a vital tool to fully establish TORC-2’s functions.