An antibody to tumour necrosis factor ligand superfamily member 15 (TNFSF15). Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis.
Catalogue number crb2005778 Antibody Anti-TNFSF15 antibody Antigen Peptide KLH conjugated synthetic peptide crb1200987 Protein ID UniProtKB - O95150 (Human) Aliases Tumor necrosis factor ligand superfamily member 15, TNF ligand-related molecule 1, Vascular endothelial cell growth inhibitor Cross-Reactivity Human Host Species Rabbit Antibody Type Polyclonal Concentration 2.0 mg/ml Glycine Target Tumor necrosis factor ligand superfamily member 15 Family Tumor necrosis factor family Storage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/thaw cycles. References
Schreiber and Podack, (2013). Immunobiology of TNFSF15 and TNFRSF25. Immunol Res 57: 3. doi: 10.1007/s12026-013-8465-0.
TNFSF15 is constitutively expressed by endothelial cells, especially vascular endothelial cells in the kidney and prostate, but can also be induced by IL-1β or TNFα. For other tissues, particularly immune cells, the expression of TNFSF15 is transient. TNFSF15 provides a stimulatory signal to T cell subsets, enhancing effector activity and proliferation. TNFSF15 interaction with receptor DR3 in macrophages induces bacterial uptake and promotes intracellular bacterial clearance via reactive oxygen species, nitric oxide synthase 2, and autophagy up-regulation. For these cells, constitutive expression of TNFSF15 results in increased severity of immunopathology.
TNFSF15 is the only ligand for TNFRSF25. Interaction of TNFSF15 with TNFRSF25 in several cell lines is associated with NFκB activation and induction of apoptosis.
A single nucleotide polymorphism in TNFSF15 is associated with Crohn’s disease. At the same time, several polymorphisms in TNFSF15 are associated with the incidence of inflammatory bowel disease. polymorphisms in TNFSF15 may also be important for developing spondyloarthropathy, primary biliary cirrhosis and leprosy.