An antibody raised against mouse Tas2r139, a putative taste receptor that also interacts with bacterial molecules to activate the immune response.
Catalogue number crb2005724 Antibody Anti-Tas2r139 antibody Antigen Peptide KLH conjugated synthetic peptide crb1200933 Protein ID UniProtKB - Q7TQA5 Aliases Tas2r39, T2R39, mT2R34 Cross-Reactivity Mouse Host Species Rabbit Antibody Type Polyclonal Concentration 2.0 mg/ml Glycine (R1G), 0.2 mg/ml TEA (R1T), 2.0 mg/ml Glycine (R2G), 0.2 mg/ml TEA (R2T) Target Tas2r139 Family G-protein coupled receptor T2R family Storage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/thaw cycles. References
Conte et al., (2003). Evolutionary relationships of the Tas2r receptor gene families in mouse and human. Physiol Genom., 14(1): 73. doi: 10.1152/physiolgenomics.00060.2003.
Gopallawa et al., (2021). Bitter taste receptors stimulate phagocytosis in human macrophages through calcium, nitric oxide, and cyclic-GMP signaling. Cell. Mol. Life Sci., 78: 271. doi: 10.1007/s00018-020-03494-y.
Mouse models help study the responses of bitter taste receptors (TAS2Rs). TAS2Rs are predominantly found in the mouth and tissue, including the gut and lungs, and cell types such as immune cells like neutrophils. Taste receptor type 2 member 39 (Tas2r139) is a receptor that may play a role in the perception of bitterness. This receptor has been identified as the homolog of human TAS2R39. However, activation of the homolog differs and is helpful for comparison. For example, (-)-epicatechin gallate, typical catechin, activates human TAS2R39 but not Tas2r139. Tas2r39 did respond to resveratrol as determined by calcium assays; this is also seen with human TAS2R39.
This polyclonal antibody reacts to mouse Tas2r139; we also have an antibody to the human homolog TAS2R39 available here.