Antibody raised against SLIT2; acts as a molecular guidance cue in cellular migration, mediated by interactions with roundabout homologue receptors.
Catalogue number crb2005695 Antibody Anti-SLIT2 antibody Antigen Peptide KLH conjugated synthetic peptide crb1200904 Protein ID UniProtKB - O94813 Aliases Slit homolog 2, Slit-2 Cross-Reactivity Human Host Species Rabbit Antibody Type Polyclonal Concentration 2mg/ml Glycine (R1G), 2mg/ml Glycine (R2G), 0.5mg/ml TEA (R2T) Target SLIT2 Storage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/thaw cycles.
SLIT genes encode the secreted ligands used for regulation of axon branching, pathfinding and neuronal migration. The secretory protein Slit homolog 2 (Slit2) and its transmembrane receptor protein Robo1 are evolutionarily conserved molecules thought to regulate axon guidance and neuronal cell migration.
Roundabout homologue 1 (Robo1) is the major Slit2 receptor, used to mediate the function of Slit homologue proteins needed for guiding major forebrain projections during neuronal development. Secreted Slit2 proteins mediate chemorepulsive signals on cells expressing robo1 receptors, allowing the normal growth and migrations of axons in the developing brain. Robo2 is also a receptor protein for the ligand Slit1, with these receptor-ligand interactions being necessary for proper ganglion formation.
Although primarily known for involvement in neuronal signalling, Slit/Robo signalling is involved in cell proliferation and cell mortality in a range of cell and tissue types.