Anti-SLIT2 antibody
Description
Application Data
Description
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Antibody raised against SLIT2; acts as a molecular guidance cue in cellular migration, mediated by interactions with roundabout homologue receptors.
Application Data
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Material Safety Data Sheet (MSDS)Catalogue number crb2005661 Antibody Anti-SLIT2 antibody Antigen Peptide KLH conjugated synthetic peptide crb1200870e Protein ID O94813 SLIT2 Aliases Slit homolog 2, Slit-2 Cross-Reactivity Mouse Target Protein Species Mouse Host Species Rabbit Antibody Type Polyclonal Concentration 0.5mg/ml Glycine (R1G), 0.1mg/ml TEA (R2T) Target SLIT2 Storage Stabilisers The product should be stored at -20°C for short term storage and long term storage. Avoid repeated freeze/ thaw cycles. Storage The product should be stored at -20°C for short term storage and long term storage. Avoid repeated freeze/ thaw cycles. References Grieshammer, U., et al. (2004). SLIT2-Mediated ROBO2 Signalling Restricts Kidney Induction to a Single Site. Developmental Cell, 6(5), pp.709–717.
Lopez-Bendito, G., et al. (2007). Robo1 and Robo2 Cooperate to Control the Guidance of Major Axonal Tracts in the Mammalian Forebrain. Journal of Neuroscience, 27(13), pp.3395–3407.
Mertsch, S., et al. (2007). Slit2 involvement in glioma cell migration is mediated by Robo1 receptor. Journal of Neuro-Oncology, 87(1), pp.1–7.
SLIT genes encode the secreted ligands used for regulation of axon branching, pathfinding and neuronal migration. The secretory protein Slit homolog 2 (Slit2) and its transmembrane receptor protein Robo1 are evolutionarily conserved molecules thought to regulate axon guidance and neuronal cell migration.
Roundabout homologue 1 (Robo1) is the major Slit2 receptor, used to mediate the function of Slit homologue proteins needed for guiding major forebrain projections during neuronal development. Secreted Slit2 proteins mediate chemorepulsive signals on cells expressing robo1 receptors, allowing the normal growth and migrations of axons in the developing brain. Robo2 is also a receptor protein for the ligand Slit1, with these receptor-ligand interactions being necessary for proper ganglion formation.
Although primarily known for involvement in neuronal signalling, Slit/Robo signalling is involved in cell proliferation and cell mortality in a range of cell and tissue types.