Anti-Slc34a3 antibody

  • Description

  • Application Data

Description

Recognises Sodium-dependent phosphate transport protein 2C which mediates phosphate homeostasis in the kidney.

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Application Data

Catalogue number crb2005640
Antibody Anti-Slc34a3 antibody
Antigen Peptide KLH conjugated synthetic peptide crb1200849e
Protein ID Q8K4R8 Rat Slc34a3
Aliases Sodium-dependent phosphate transport protein 2C, Sodium-phosphate transport protein 2C, Slc34a3, Sodium/phosphate cotransporter 2C, Na+-dependent phosphate cotransporter 2C, Na+/Pi cotransporter 2C, NaPi-2c, Solute carrier family 34
Cross-Reactivity Rat
Host Species Rabbit
Antibody Type Polyclonal
Concentration 1mg/ml Glycine (R1G), 1mg/ml Glycine (R2G)
Validation 1:1000 (ELISA)
Target Slc34a3
Citations

Segawa, H., Kaneko, I., Takahashi, A., Kuwahata, M., Ito, M., Ohkido, I., Tatsumi, S. and Miyamoto, K.I., (2002). Growth-related renal type II Na/Pi cotransporter. Journal of Biological Chemistry, 277(22), pp.19665-19672.

Segawa, H., Onitsuka, A., Kuwahata, M., Hanabusa, E., Furutani, J., Kaneko, I., Tomoe, Y., Aranami, F., Matsumoto, N., Ito, M. and Matsumoto, M., (2009). Type IIc sodium–dependent phosphate transporter regulates calcium metabolism. Journal of the American Society of Nephrology, 20(1), pp.104-113.

Lorenz-Depiereux, B., Benet-Pages, A., Eckstein, G., Tenenbaum-Rakover, Y., Wagenstaller, J., Tiosano, D., Gershoni-Baruch, R., Albers, N., Lichtner, P., Schnabel, D. and Hochberg, Z.E., (2006). Hereditary hypophosphatemic rickets with hypercalciuria is caused by mutations in the sodium-phosphate cotransporter gene SLC34A3. The American Journal of Human Genetics, 78(2), pp.193-201.

References

Segawa, H., Kaneko, I., Takahashi, A., Kuwahata, M., Ito, M., Ohkido, I., Tatsumi, S. and Miyamoto, K.I., (2002). Growth-related renal type II Na/Pi cotransporter. Journal of Biological Chemistry, 277(22), pp.19665-19672.

Segawa, H., Onitsuka, A., Kuwahata, M., Hanabusa, E., Furutani, J., Kaneko, I., Tomoe, Y., Aranami, F., Matsumoto, N., Ito, M. and Matsumoto, M., (2009). Type IIc sodium–dependent phosphate transporter regulates calcium metabolism. Journal of the American Society of Nephrology, 20(1), pp.104-113.

Lorenz-Depiereux, B., Benet-Pages, A., Eckstein, G., Tenenbaum-Rakover, Y., Wagenstaller, J., Tiosano, D., Gershoni-Baruch, R., Albers, N., Lichtner, P., Schnabel, D. and Hochberg, Z.E., (2006). Hereditary hypophosphatemic rickets with hypercalciuria is caused by mutations in the sodium-phosphate cotransporter gene SLC34A3. The American Journal of Human Genetics, 78(2), pp.193-201.

Material Safety Data Sheet (MSDS)

Sodium-dependent phosphate transport protein 2C is involved in maintaining the homeostasis of inorganic phosphate (Pi) at the renal brush border membrane. Pi is needed for growth, repair and development of bones and teeth. This cotransporter is more abundant in weaning animals than adults because growth and development are more important at this stage in their lifespan.

The homologue of sodium-dependent phosphate transport protein 2C in humans also plays a role in calcium metabolism and subsequently bone mineralisation. Pi and calcium are needed for neuromuscular function and skeleton mineralisation and the levels of both in the blood act antagonistically. In humans, a gene mutations to sodium-dependent phosphate transport protein 2C result in loss of function, is associated with hereditary hypophosphatemic rickets with hypercalciuria (HHRH), which is a rare autosomal recessive disorder in which blood phosphate levels are low (hypophosphatemia) and calcium excretion levels are high (hypercalciuria).

Anti-Slc34a3 antibody

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20ug£50.00
20ug£50.00
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