An antibody against sphingosine 1-phosphate receptor 1 (S1PR1); a mediator of autoimmune conditions including asthma and multiple sclerosis.
Catalogue number crb2005731 Antibody Anti-S1PR1 antibody Antigen Peptide KLH conjugated synthetic peptide crb1200940 Protein ID UniProtKB - P21453 Aliases Sphingosine 1-phosphate receptor 1, S1P receptor 1, S1P1, Endothelial differentiation G-protein coupled receptor 1, Sphingosine 1-phosphate receptor Edg-1 (S1P receptor Edg-1) Cross-Reactivity Human Host Species Rabbit Antibody Type Polyclonal Concentration 0.4 mg/ml Glycine (R2G) Target S1PR1 Family G-protein coupled receptor 1 family Storage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/thaw cycles. References
Gaengel et al., (2012). The sphingosine-1-phosphate receptor S1PR1 restricts sprouting angiogenesis by regulating the interplay between VE-cadherin and VEGFR2. Dev. cell, 23(3): 587. doi: 10.1016/j.devcel.2012.08.005.
Xiao et al., (2019). S1P-S1PR1 signaling: the “Sphinx” in osteoimmunology. Front. Immunol., 10: 1409. doi: 10.3389/fimmu.2019.01409.
Sphingolipids are essential lipids in eukaryotic cells. The sphingosine 1-phosphate receptor 1 (S1PR1) mediates several autoimmune conditions, including asthma and multiple sclerosis (MS). Therefore, sphingolipid derivatives are a target to block the activation of G-protein coupled receptor S1PR1 and suppress autoimmune conditions.
S1PR1 plays an important role in cell migration, probably via its role in the reorganisation of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. S1PR1 activation is also required for endothelial cell chemotaxis and PDGF-induced cell motility.
S1PR1 has complex and vital roles required for normal embryonic heart development and cardiac morphogenesis. S1PR1 also plays an important role in regulating sprouting angiogenesis and vascular maturation. S1PR1 inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development.
S1PR1 is a regulator of bone mineralisation and bone homeostasis.