Anti-ROBO2 antibody
Description
Application Data
Description
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Antibody raised against ROBO2; a receptor for SLIT2, acting as molecular guidance cues in cellular migration and axon navigation.
Application Data
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Material Safety Data Sheet (MSDS)Catalogue number crb2005659 Antibody Anti-ROBO2 antibody Antigen Peptide KLH conjugated synthetic peptide crb1200868e Protein ID F8W703 ROBO2 Aliases Roundabout Homologue 2, ROBO2, KIAA1568 Host Species Rabbit Antibody Type Polyclonal Concentration 2mg/ml Glycine (R1G), 1mg/ml Glycine (R2G) Target ROBO2 Storage Stabilisers The product should be stored at -20°C for short term storage and long term storage. Avoid repeated freeze/ thaw cycles. Family ROBO family Storage The product should be stored at -20°C for short term storage and long term storage. Avoid repeated freeze/ thaw cycles. References Jaworski, A., Long, H. and Tessier-Lavigne, M. (2010). Collaborative and Specialized Functions of Robo1 and Robo2 in Spinal Commissural Axon Guidance. Journal of Neuroscience, 30(28), pp.9445–9453.
Lopez-Bendito, G., et al. (2007). Robo1 and Robo2 Cooperate to Control the Guidance of Major Axonal Tracts in the Mammalian Forebrain. Journal of Neuroscience, 27(13), pp.3395–3407.
Shiau, C.E., Lwigale, P.Y., Das, R.M., Wilson, S.A. and Bronner-Fraser, M. (2008). Robo2-Slit1 dependent cell-cell interactions mediate assembly of the trigeminal ganglion. Nature Neuroscience, 11(3), pp.269–276.
Roundabout homologue 1 (Robo1) and Roundabout homologue 2 (Robo2) cooperate to mediate the function of Slit homologue proteins, used in guiding major forebrain projections during neuronal development. Robo2 is a receptor protein for the ligand Slit1, with these receptor-ligand interactions being necessary for proper ganglion formation.
Robo1 and Robo2 are used in separate, specialised processes in post midline crossing axons. Robo1 is needed to prevent axons from stalling immediately post crossing, whereas Robo2 is required for axons to project away from the floor plate and into the lateral funiculus.
Robo2 also plays a key role in the formation of the ureteric bud, during the development of the kidneys. The SLIT-ROBO pathways are involved in the pancreas, however the exact function of this still remains unclear.