Anti-PYY antibody

  • Description

  • Application Data


An antibody raised against peptide YY. PYY is a hunger-suppressing hormone secreted in the mucosa of the rectum, colon and distal ileum.

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Application Data

Catalogue number crb2005718
Antibody Anti-PYY antibody
Antigen Peptide KLH conjugated synthetic peptide crb1200927
Protein ID UniProtKB - P10082
Aliases Peptide YY, PYY, PYY-I , Peptide tyrosine tyrosine
Cross-Reactivity Human
Host Species Rabbit
Antibody Type Polyclonal
Concentration 2.0 mg/mL Glycine (R1G), 0.2 mg/mL TEA (R1T), 2.0 mg/mL Glycine (R2G), 0.2 mg/mL TEA (R2T)
Target PYY
Family NPY family
Storage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/thaw cycles.

Gheller et al., (2019). Peptide YY (PYY) is expressed in human skeletal muscle tissue and expanding human muscle progenitor cells. Front. physiol., 10: 188. doi: 10.3389/fphys.2019.00188.

Guida et al., (2018). Sitagliptin and Roux‐en‐Y gastric bypass modulate insulin secretion via regulation of intra‐islet PYY. Diabetes Obes Metab.20(3): 571. doi: 10.1111/dom.13113.

Data Sheet Data Sheet Data Sheet Data Sheet Material Safety Data Sheet (MSDS)

PYY (peptide YY) regulates body mass index and body weight, where decreased levels of PYY are associated with obesity and increased BMI. It reduces hunger and food intake, gastrointestinal motility and hormone secretion by the pancreas. It also plays a role in regulating energy homeostasis. Studies suggest that its expression is decreased under pro-inflammatory stimuli and during the differentiation of monocytes to macrophages. PYY concentrations are also reduced in women with high dietary cognitive restraint (CR) compared to women with normal CR. This peptide is altered in various gastrointestinal disorders and might be one of the causes of chronic idiopathic slow-transit constipation (CST). It might also be responsible for the symptoms of inflammatory bowel disease and gastroenteropathy due to long-standing diabetes. However, in some gastrointestinal disorders, it might have a positive role, as in the case of systemic sclerosis, celiac disease, and post-intestinal resection state.

Anti-PYY antibody

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