Anti-PYY antibody
Description
Application Data
Description
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An antibody raised against peptide YY. PYY is a hunger-suppressing hormone secreted in the mucosa of the rectum, colon and distal ileum.
Application Data
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Data Sheet Data Sheet Data Sheet Data Sheet Material Safety Data Sheet (MSDS)Catalogue number crb2005718 Antibody Anti-PYY antibody Antigen Peptide KLH conjugated synthetic peptide crb1200927 Protein ID UniProtKB - P10082 Aliases Peptide YY, PYY, PYY-I , Peptide tyrosine tyrosine Cross-Reactivity Human Host Species Rabbit Antibody Type Polyclonal Concentration 2.0 mg/mL Glycine (R1G), 0.2 mg/mL TEA (R1T), 2.0 mg/mL Glycine (R2G), 0.2 mg/mL TEA (R2T) Target PYY Family NPY family Storage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/thaw cycles. References Gheller et al., (2019). Peptide YY (PYY) is expressed in human skeletal muscle tissue and expanding human muscle progenitor cells. Front. physiol., 10: 188. doi: 10.3389/fphys.2019.00188.
Guida et al., (2018). Sitagliptin and Roux‐en‐Y gastric bypass modulate insulin secretion via regulation of intra‐islet PYY. Diabetes Obes Metab., 20(3): 571. doi: 10.1111/dom.13113.
PYY (peptide YY) regulates body mass index and body weight, where decreased levels of PYY are associated with obesity and increased BMI. It reduces hunger and food intake, gastrointestinal motility and hormone secretion by the pancreas. It also plays a role in regulating energy homeostasis. Studies suggest that its expression is decreased under pro-inflammatory stimuli and during the differentiation of monocytes to macrophages. PYY concentrations are also reduced in women with high dietary cognitive restraint (CR) compared to women with normal CR. This peptide is altered in various gastrointestinal disorders and might be one of the causes of chronic idiopathic slow-transit constipation (CST). It might also be responsible for the symptoms of inflammatory bowel disease and gastroenteropathy due to long-standing diabetes. However, in some gastrointestinal disorders, it might have a positive role, as in the case of systemic sclerosis, celiac disease, and post-intestinal resection state.