Anti-phosphorylated NR2B (pS1303) antibody

£220.00
  • Description

  • Application Data

Description

Recognises the NR2B subunit of NMDA receptors phosphorylated at serine residue 1303

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Application Data

Catalogue number crb2005002e
Disease Area Neurodegenerative diseases
Antibody Anti-phosphorylated NR2B (pS1303) antibody
Antigen Peptide KLH conjugated synthetic peptide crb1200273
Protein ID UniProtKB - Q00960
Aliases GRIN2B, GluN2B, MRD6, NMDAR2B, NR2B, hNR3, EIEE27, glutamate ionotropic receptor NMDA type subunit 2B, NMDA NR2B Subunit
Cross-Reactivity (predicted Human, Mouse)
Host Species Anti-Rabbit
Antibody Type Polyclonal
Label Unconjugated
Concentration 1mg/ml
Validation WB/ELISA/IHC
Target phosphorylated NR2B (pS1303)
Specificity PTM - Phospho ser 1303
Post-translational Modification Phosphorylation of Serine 1303
Storage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/thaw cycles.
Citations

Li, Y., Sun, W., Han, S., Li, J., Ding, S., Wang, W. and Yin, Y. (2016). IGF-1-Involved Negative Feedback of NR2B NMDA Subunits Protects Cultured Hippocampal Neurons Against NMDA-Induced Excitotoxicity. Mol Neurobiol, 54(1), 684-696. PMID: 26758454

 

Liao, G. Y., Wagner. D. A., Hsu, M. H., Leonard, J. P. (2001). Evidence for direct protein kinase-C mediated modulation of N-methyl-D-aspartate receptor current. Mol Pharmacol, 59(5), 960-964. PMID: 11306676

 

Wang, Y., Han, S., Han, R., Su, Y. and Li, J. (2017). Propofol-induced downregulation of NR2B membrane translocation in hippocampus and spatial memory deficits of neonatal mice. Brain and Behav, 7(7), e00734. PMID: 28729940

References

Li, Y., Sun, W., Han, S., Li, J., Ding, S., Wang, W. and Yin, Y. (2016). IGF-1-Involved Negative Feedback of NR2B NMDA Subunits Protects Cultured Hippocampal Neurons Against NMDA-Induced Excitotoxicity. Mol Neurobiol, 54(1), 684-696. PMID: 26758454

 

Liao, G. Y., Wagner. D. A., Hsu, M. H., Leonard, J. P. (2001). Evidence for direct protein kinase-C mediated modulation of N-methyl-D-aspartate receptor current. Mol Pharmacol, 59(5), 960-964. PMID: 11306676

 

Wang, Y., Han, S., Han, R., Su, Y. and Li, J. (2017). Propofol-induced downregulation of NR2B membrane translocation in hippocampus and spatial memory deficits of neonatal mice. Brain and Behav, 7(7), e00734. PMID: 28729940

Data Sheet Material Safety Data Sheet (MSDS)

N-methyl-D-aspartate receptors (NMDARs) are ligand-gated ionotropic glutamate receptors that mediate excitatory synaptic transmission and are important for many aspects of nervous system function including: synaptic plasticity; learning and memory; neuronal development and circuit formation. NMDARs have also been implicated in various neuronal disorders. NMDARs are heteromers consisting of an obligate NR1 and most commonly one or two kinds of NR2 subunits or occasionally NR3 subunits.

NR2B is the predominant subunit found in the postnatal brain, however over time NRA2 levels increase and eventually outnumber NR2B subunits in a process known as the NR2B-NR2A developmental switch. The greater ratios of the NR2B subunit in post-natal brains leads to NMDA receptors which remain open longer compared to those with more NR2A subunits, and may be related to the greater memory abilities in the immediate postnatal period compared to late in life.

The phosphorylation of NR2B is closely linked to its transport and the phosphorylation of NR2B at Ser1303 is an initial step of NMDA‐induced excitotoxicity. NR2B is phosphorylated at Ser1303 by protein kinase C (PKC) and is dephosphorylated by protein phosphatase 1 (PP1).

The involvement of NMDAR in the central nervous system (CNS) has become a focus area for neurodegenerative diseases such as Alzheimer’s disease, epilepsy and ischemic neuronal cell death.

Anti-phosphorylated NR2B (pS1303) antibody

50ug
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