Anti-PERK antibody
Description
Application Data
Description
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Recognizes integrated stress response (ISR) kinase, PERK
Application Data
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Catalogue number | crb2005276 |
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Antibody | Anti-PERK antibody |
Antigen Peptide | Drosophila PERK kinase domain recombinant protein |
Protein ID | UniProtKB - Q9NIV1 (E2AK3_DROME) |
Aliases | Drosophila PEK (pancreatic eIF2α kinase), CG2087, Drosophila Eukaryotic translation initiation factor 2-alpha kinase (E2AK3) |
Cross-Reactivity | Drosophila melanogaster |
Host Species | Rabbit |
Antibody Type | Polyclonal |
Concentration | antiserum |
Validation | 1:1000 (WB) |
Disease Area | Unfolded protein response, Wolcott Rallison Syndrome / diabetes mellitus |
Family | eIF2α kinases |
Recognizes Integrated stress response (ISR) kinase, PERK, with a strong signal and low background noise.
When there are a large number of misfolded proteins in the cell a homeostatic mechanism called the unfolded protein response (UPR) is activated which involves restricting translation and increasing chaperone capacity. As part of this response, the ER-resident kinase PERK (eukaryotic translation initiation factor 2α kinase, also known as PEK) phosphorylates the translation initiation factor eIF2α resulting in the attenuation of translation.
PERK activation causes loss of cyclin D1 and G1 cell cycle arrest, negatively regulating cell proliferation. PERK-dependent activation of GSK3β during ER stress has been shown to destabilise p53.