An antibody to Period circadian protein homolog 3 (Per3); a key regulator of sleep and in various processes.
Catalogue number crb2005754 Antibody Anti-Per3 antibody Antigen Peptide KLH conjugated synthetic peptide crb1200963 Protein ID UniProtKB - Q8CJE2 (Rat), O70361 (Mouse) Aliases Period circadian protein homolog 3, Circadian clock protein PERIOD 3, mPER3 Cross-Reactivity Rat, Mouse Host Species Rabbit Antibody Type Polyclonal Concentration 1.0 mg/ml Glycine Target Period circadian protein homolog 3 Storage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/thaw cycles. References
Archer et al., (2018). Phenotyping of PER3 variants reveals widespread effects on circadian preference, sleep regulation, and health. Sleep Med. Rev., 40: 109. doi: 10.1016/j.smrv.2017.10.008.
Liberman et al., (2017). Circadian clock model supports molecular link between PER3 and human anxiety. Sci. reps, 7(1): 9893. doi: 10.1038/s41598-017-07957-4.
Disruptions in the circadian rhythm are factors in developing cardiovascular disease, cancer, anxiety and ageing. A feedback loop is a key mechanism regulating the molecular circadian clock. Per3 is a transcriptional repressor and also regulates temporal organisation in peripheral tissues. Per3, with other proteins, forms the negative pathway of the feedback loop; Per3 interacts with the NPAS2-BMAL1/BMAL2 heterodimer inhibiting transcriptional activity and thereby negatively regulating Per3’s own expression. Per3 is one of the most robustly rhythmic expressed genes.
Per3 has a redundant role with the other Per proteins Per1 and Per2 and is not essential for maintaining the circadian rhythm. However, Per3 is vital in sleep periods through transcriptional regulation of sleep homeostasis-related genes. Polymorphisms appear to influence sleep regulation and circadian preference. Other polymorphisms have been linked to increased anxiety.