Anti-P2X5 antibody
Description
Application Data
Description
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An antibody raised against P2X5; is an ATP receptor which acts as a ligand-gated ion channel. A regulator of inflammation.
Application Data
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Data Sheet Material Safety Data Sheet (MSDS)Catalogue number crb2005753 Antibody Anti-P2X5 antibody Antigen Peptide KLH conjugated synthetic peptide crb1200962 Protein ID UniprotKB - Q93086 (Human) Aliases P2X purinoceptor 5, ATP receptor, Purinergic receptor Cross-Reactivity Human Host Species Rabbit Antibody Type Polyclonal Concentration 1 mg/ml Glycine Target P2X purinoceptor 5 Storage Stabilisers The product should be stored at -20°C for short term storage and long term storage. Avoid repeated freeze/ thaw cycles. Family P2X receptor family Storage The product should be stored at -20°C for short term storage and long term storage. Avoid repeated freeze/ thaw cycles. References Kim et al., (2018). The purinergic receptor P2X5 contributes to bone loss in experimental periodontitis. BMB Reports, 51(9): 468. doi: 10.5483/BMBRep.2018.51.9.126.
King (2022). Rehabilitation of the P2X5 receptor: a re-evaluation of structure and function. Purinergic Signalling. doi: 10.1007/s11302-022-09903-0.
Purinergic receptor P2X 5 (P2X5) ligand-gated ion channel by extracellular ATP. Alternative splicing results in multiple transcript variants. Exon-skipping generates a non-functional isoform of the P2X5 subunit. P2X5 is enriched in naive B-cells, memory B-cells, and intestinal tissue. The P2X receptor (1-7) channels assemble as three P2X subunits either as homomeric or heterotrimeric assemblies.
The P2X5 receptor is a regulator of inflammation and inflammatory bone loss. P2X5 activates the full inflammasome-induced IL-1β production by osteoclasts. P2X5 directly regulates the maturation of osteoclasts. There is evidence P2X5 signalling plays a role in periodontitis disease progression and could be a target for treating oral disease and possibly other bone loss disorders.