Anti-p21 antibody

  • Description

  • Application Data


Anti-p21 antibody corresponding to a region of the human p21 protein sequence.

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Application Data

Catalogue number crb2005030
Antibody Anti-p21 antibody
Antigen Peptide KLH conjugated synthetic peptide crb1200312e
Protein ID UniProtKB - P38936
Aliases Cyclin-dependent kinase inhibitor 1, CDKN1, CDK-Interacting Protein 1, CIP1, Wild-Type P53-Activated Fragment 1, WAF1, Melanoma Differentiation Associated Protein 6, MDA6
Cross-Reactivity Human
Host Species Rabbit
Antibody Type Polyclonal
Concentration 1mg/ml
Validation 1:1000 (WB), 1:1000 (ELISA)
Target p21
Disease Area Cell Cycle, DNA Damage, Senescence, Apoptosis
Specificity Protein
Material Safety Data Sheet (MSDS)

The multi-functional cyclin-dependent kinase (CDK) inhibitor p21, also known as p21WAF1/Cip1 or CDKN1A functions as a cell cycle inhibitor and anti-proliferative effector. Upon DNA damage and genotoxic stress, the tumour suppressor p53 is activated and induces the expression of p21. p21 has also been implicated in nucleotide excision repair (NER), base excision repair (BER) and DNA translesion synthesis (TLS) by disrupting the proliferating cell nuclear antigen (PCNA) interaction with other DNA repair factors and promoting PCNA degradation.

Anti-p21 antibody

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