Anti-p21 antibody
Description
Application Data
Description
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Anti-p21 antibody corresponding to a region of the human p21 protein sequence.
Application Data
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University of Liverpool.
The multi-functional cyclin-dependent kinase (CDK) inhibitor p21, also known as p21WAF1/Cip1 or CDKN1A functions as a cell cycle inhibitor and anti-proliferative effector. Upon DNA damage and genotoxic stress, the tumour suppressor p53 is activated and induces the expression of p21. p21 has also been implicated in nucleotide excision repair (NER), base excision repair (BER) and DNA translesion synthesis (TLS) by disrupting the proliferating cell nuclear antigen (PCNA) interaction with other DNA repair factors and promoting PCNA degradation.
The multi-functional cyclin-dependent kinase (CDK) inhibitor p21, also known as p21WAF1/Cip1 or CDKN1A functions as a cell cycle inhibitor and anti-proliferative effector. Upon DNA damage and genotoxic stress, the tumour suppressor p53 is activated and induces the expression of p21. p21 has also been implicated in nucleotide excision repair (NER), base excision repair (BER) and DNA translesion synthesis (TLS) by disrupting the proliferating cell nuclear antigen (PCNA) interaction with other DNA repair factors and promoting PCNA degradation.
| Catalogue number | crb2005030 |
|---|---|
| Antibody | Anti-p21 antibody |
| Antigen Peptide | KLH conjugated synthetic peptide crb1200312e |
| Protein ID | UniProtKB - P38936 |
| Aliases | Cyclin-dependent kinase inhibitor 1, CDKN1, CDK-Interacting Protein 1, CIP1, Wild-Type P53-Activated Fragment 1, WAF1, Melanoma Differentiation Associated Protein 6, MDA6 |
| Cross-Reactivity | Human |
| Host Species | Rabbit |
| Antibody Type | Polyclonal |
| Concentration | 1mg/ml |
| Validation | 1:1000 (WB), 1:1000 (ELISA) |
| Target | p21 |
| Disease Area | Cell Cycle, DNA Damage, Senescence, Apoptosis |
| Specificity | Protein |
The multi-functional cyclin-dependent kinase (CDK) inhibitor p21, also known as p21WAF1/Cip1 or CDKN1A functions as a cell cycle inhibitor and anti-proliferative effector. Upon DNA damage and genotoxic stress, the tumour suppressor p53 is activated and induces the expression of p21. p21 has also been implicated in nucleotide excision repair (NER), base excision repair (BER) and DNA translesion synthesis (TLS) by disrupting the proliferating cell nuclear antigen (PCNA) interaction with other DNA repair factors and promoting PCNA degradation.