Anti-Osteopontin antibody

  • Description

  • Application Data


Antibody raised against osteopontin; involved in bone metabolism, bone-related diseases and vascular diseases.

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Application Data

Catalogue number crb2005745
Antibody Anti-Osteopontin antibody
Antigen Peptide KLH conjugated synthetic peptide crb1200954
Protein ID UniProtKB - P08721 (Rat), P10923 (Mouse)
Aliases Bone sialoprotein 1, Secreted phosphoprotein 1 (SPP-1)
Cross-Reactivity Rat, Mouse
Host Species Rabbit
Antibody Type Polyclonal
Concentration 2.0 mg/ml Glycine
Target Osteopontin
Family Osteopontin family
Storage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/thaw cycles.

Lok et al., (2019). Osteopontin in vascular disease: friend or foe?. Arterioscler. Thromb. Vasc. Biol.39(4): 613-622. doi: 10.1161/ATVBAHA.118.311577.

Si et al., (2020). Osteopontin in Bone Metabolism and Bone Diseases. Int. J. Clin. Exp. Med., 26: e919159-1. doi: 10.12659/MSM.919159.

Data Sheet Material Safety Data Sheet (MSDS)

Osteopontin (OPN) is in the small integrin-binding ligand N-linked glycoprotein (SIBLING) family. Osteopontin is a secreted matricellular cytokine with an important role in bone mass regulation. OPN is involved in osteoclast attachment to the mineralised bone matrix. The regulation of OPN is linked to the development of several bone-related diseases, including osteoporosis, rheumatoid arthritis, and osteosarcoma. It is a transformation-associated protein that binds to the integrin and CD44 cell membrane surface receptors. These receptors are correlated with biomineralisation, cell-mediated immunity, inflammation, fibrosis, as well as cell survival, tumorigenesis, and metastasis. OPN also has a role in cardiac health; acute increases can be protective, but chronic increases are linked to cardiovascular disease and other vascular diseases.

Anti-Osteopontin antibody

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