Anti-Nduf11a antibody

  • Description

  • Application Data


Antibody raised against Caenorhabditis elegans NDUF-11, the NDUFA11 homolog. NDUF-11 is part of mitochondrial complex I and the supercomplex; it is vital for complex I stability and normal respiratory function.

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Application Data

Catalogue number crb2005311
Disease Area Encephalocardiomyopathy, Fatal infantile lactic acidemia, Research Area: Bioenergetics; electron transfer
Antibody Anti-Nduf11a antibody
Antigen Peptide KLH conjugated synthetic peptide crb1200537e
Protein ID Q17512
Aliases CELE_B0491.5, B14.7, CI-B14.7, NADH:ubiquinone oxidoreductase subunit A11, MC1DN14
Cross-Reactivity C.Elegans
Host Species Rabbit
Antibody Type Polyclonal
Concentration 1 mg/ml Glycine eluate
Target B0491.5 C.Elegans (NDUFA11 homolog)
Family Tim17 family
Storage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/ thaw cycles.
Citations Knapp-Wilson et al., (2021). Maintenance of complex I and its supercomplexes by NDUF-11 is essential for mitochondrial structure, function and health. J. Cell Sci., 134(13): jcs258399. PMID: 34106255.
Material Safety Data Sheet (MSDS)

Mitochondria contain 4 multimeric electron transfer complexes (CI-CIV) that allow a stepwise transfer of electrons leading to energy production. The electron transfer complexes can form supercomplexes with a core of monomeric CI and dimeric CIII. The purpose of the supercomplex is believed to be direct electron transfer in a discrete unit with additional structural roles in the mitochondria. NDUFA11 is a conserved integral membrane protein that sits at the interface of CI and CIII. Lack of functional NDUFA11 leads to infant death, and encephalocardiomyopathy.

Understanding NDUFA11 roles could be key to understanding mitochondrial diseases. This antibody is for the NDUFA11 homolog (NDUF-11) in the genetically tractable model Caenorhabditis elegans and has already provided insights. The C. elegans NDUF-11 subunit is integral for CI stability and the supercomplex. Loss of complex stability altered mitochondrial function, morphology and ultimately lead to premature death. Further work with this antibody will help understand NDUF-11 functions and possible roles in mitochondrial disorders.

Anti-Nduf11a antibody

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