Anti-MKP1 antibody

  • Description

  • Application Data

Description

Recognises human MKP1 protein, a bispecific phosphatase involved in the regulation of apoptosis

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Application Data

Catalogue number crb2005260
Antibody Anti-MKP1 antibody
Antigen Peptide KLH conjugated synthetic peptide crb1200502e
Protein ID UniProtKB - P28562
Aliases Dual specificity protein phosphatase 1, DUSP1
Cross-Reactivity Human, Mouse
Target Protein Species Human, Mouse
Host Species Rabbit
Antibody Type Polyclonal
Concentration 1 mg/ml
Validation (WB) 1:1000 (ELISA)
Target MKP1
Storage Stabilisers This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/ thaw cycles.
Family protein-tyrosine phosphatase family
Super Family Non-receptor class dual specificity subfamily
Disease Area Cell cycle, Stress response
Storage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/ thaw cycles.
References

Arrizabalaga et al., (2017). High expression of MKP1/DUSP1 counteracts glioma stem cell activity and mediates HDAC inhibitor response. Oncogenesis6: 401. PMID: 29284798

 

Du et al., (2020). ROCK2 disturbs MKP1 expression to promote invasion and metastasis in hepatocellular carcinoma. Am J Cancer Res10(3): 884–896. PMID: 32266097

Material Safety Data Sheet (MSDS)

MAPK phosphatases (MKPs) are able to dephosphorylate both the threonine and tyrosine residues in conserved motifs, thereby inhibiting their activity.

MKP1 is a bispecific phosphatase and an anti-apoptotic protein that plays a key role in various physiological and pathological phenomena, including tumour metastasis and invasion. MKP1 acts as a negative inhibitor of JNK, ERK1/2, and p38 MAPK and is located in the nucleus.

MKP1 plays an important role in oncogenesis, tumour progression, and resistance to chemotherapy in cancers such as ovarian, lung, or breast and glioblastoma. Activation of MKP1 might be a novel therapeutic strategy to overcome therapy resistance in glioblastoma.

Anti-MKP1 antibody

Cat No.Pack SizePriceQty.
100ug£220.00
20ug£110.00
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