Anti-MINK1 antibody
Description
Application Data
Description
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An antibody to misshapen-like kinase 1 (MINK1),a serine-threonine kinase involved in neuronal signalling, structure and cancers.
Application Data
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Data Sheet Material Safety Data Sheet (MSDS)Catalogue number crb2005777 Antibody Anti-MINK1 antibody Antigen Peptide KLH conjugated synthetic peptide crb1200986 Protein ID UniProtKB - Q8N4C8 (Human), F1LP90 (Rat) Aliases Misshapen-like kinase 1, GCK family kinase MiNK, MAPK/ERK kinase kinase kinase 6 (MEK kinase kinase 6; MEKKK 6), Misshapen/NIK-related kinase Cross-Reactivity Human, Rat Host Species Rabbit Antibody Type Polyclonal Concentration 1.0 mg/ml Glycine Target Misshapen-like kinase 1 Storage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/thaw cycles. References Avais et al., (2022). The serine/threonine kinase MINK1 directly regulates the function of promigratory proteins. J Cell Sci, 135(17): jcs259347. doi: https://doi.org/10.1242/jcs.259347.
Hussain et al., (2010). MINK and TNIK Differentially Act on Rap2-Mediated Signal Transduction to Regulate Neuronal Structure and AMPA Receptor Function. J Neurosci, 30(44): 14786. doi: 10.1523/JNEUROSCI.4124-10.2010.
Zhu et al., (2021). Priming of NLRP3 inflammasome activation by Msn kinase MINK1 in macrophages. Cell. Mol. Immunol., 18(10): 2372. doi: 10.1038/s41423-021-00761-1.
MINK1 is a serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. MINK1 is required for normal synaptic density, dendrite complexity, and surface AMPA receptor expression in hippocampal neurons. MINK1 also activates the JNK and MAPK14/p38 pathways and stimulates the stress-activated protein kinase MAPK14/p38 MAPK.
MINK1 is linked to regulating a subset of T helper cells and is implicated in developing autoimmune diseases. Additionally, MINK1 is a regulator of the activation of the inflammasome. Modulation of MINK1 could help manage inflammasome-related conditions. There is also evidence that MINK1 may have a role in developing colorectal cancer if adenomatous polyposis coli (APC) is mutated. MINK1 is a potential target for triple-negative breast cancer.
We have an antibody to the MINK1 paralog, TNIK.