Recognises metabotropic glutamate receptor 2, a G protein-coupled receptor involved in glutamate release
Western blot analysis of rat brain preparation.
Lane 1: Rat brain preparation (10µg).
Secondary: Goat anti-rabbit IgG conjugated to HRP 1:2000.
|Antigen Peptide||KLH conjugated synthetic peptide crb1200279e|
|Protein ID||UniProtKB - Q14416|
|Aliases||GRM2, GPRC1B, MGLUR2, GLUR2, mGlu2, glutamate metabotropic receptor 2, mGluR2|
|Target Protein Species||Rat, Mouse|
|Storage Stabilisers||This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/ thaw cycles.|
|Family||G-protein coupled receptor 3 family|
|Disease Area||Neurodegenerative diseases|
|Storage||This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/ thaw cycles.|
Wood, C., Wafford, K., McCarthy, A., Hewes, N., Shanks, E., Lodge, D. and Robinson, E. (2018). Investigating the role of mGluR2 versus mGluR3 in antipsychotic-like effects, sleep-wake architecture and network oscillatory activity using novel Han Wistar rats lacking mGluR2 expression. Neuropharmacology, 140, 246-259. PMID: 30005976
Yang, H., Zhang, H., Bi, G., He, Y., Gao, J. and Xi, Z. (2017). Deletion of Type 2 Metabotropic Glutamate Receptor Decreases Sensitivity to Cocaine Reward in Rats. Cell Rep, 20(2), 319-332. PMID: 28700935
Metabotropic glutamate receptors (mGluRs) are G protein-coupled receptors that have been divided into three groups based on sequence, putative signal transduction mechanisms, and pharmacologic properties. mGluR2 is a group II receptor, receptors in this group are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivity.
In humans mGluR2 is exclusively expressed in the brain where it is found in neurons as well as astrocytes, predominantly at the presynaptic terminal, although it is also expressed at the postsynaptic terminal. mGluR2 controls glutamate release and is required for generating network oscillations by mediating changes in excitatory and inhibitory neurotransmission through altering NMDA and AMPA receptor function. These oscillations are considered critical for normal central nervous system (CNS) function.
mGluR2 has been linked to the regulation of sleep and sleep disturbances as well as to the development of drug addiction and of psychiatric and neurological disorders. mGluR2 may therefore be a promising target for the treatment of such conditions.