Anti-mGluR1 antibody

  • Description

  • Application Data

Description

Recognises metabotropic glutamate receptor 1, a G protein-coupled receptor involved in glutamate neurotransmission

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Application Data

Catalogue number crb2005006
Disease Area Neurodegenerative diseases
Antibody Anti-mGluR1 antibody
Antigen Peptide KLH conjugated synthetic peptide crb1200278
Protein ID UniProtKB - Q13255
Aliases GRM1, GPRC1A, MGLU1, MGLUR1, PPP1R85, SCAR13, glutamate metabotropic receptor 1, protein phosphatase 1 regulatory subunit 85
Cross-Reactivity Rat, Mouse, Human
Host Species Rabbit
Antibody Type Polyclonal
Label Unconjugated
Concentration 1mg/ml
Validation WB/ELISA
Target mGluR1
Specificity Protein
Storage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/thaw cycles.
Citations

Bakshi, K., Parihar, R., Goswami, S., Walsh, M., Friedman, E. and Wang, H. (2014). Prenatal Cocaine Exposure Uncouples mGluR1 from Homer1 and Gq Proteins. PLoS ONE, 9(3), e91671. PMID: 24626340

 

Lopez-Chiriboga, A., Komorowski, L., Kümpfel, T., Probst, C., Hinson, S., Pittock, S. and McKeon, A. (2016). Metabotropic glutamate receptor type 1 autoimmunity. Neurology, 86(11), 1009-1013. PMID: 26888994

References

Bakshi, K., Parihar, R., Goswami, S., Walsh, M., Friedman, E. and Wang, H. (2014). Prenatal Cocaine Exposure Uncouples mGluR1 from Homer1 and Gq Proteins. PLoS ONE, 9(3), e91671. PMID: 24626340

 

Lopez-Chiriboga, A., Komorowski, L., Kümpfel, T., Probst, C., Hinson, S., Pittock, S. and McKeon, A. (2016). Metabotropic glutamate receptor type 1 autoimmunity. Neurology, 86(11), 1009-1013. PMID: 26888994

Data Sheet Material Safety Data Sheet (MSDS)

Metabotropic glutamate receptors (mGluRs) are G protein-coupled receptors that have been divided into three groups based on sequence, putative signal transduction mechanisms, and pharmacologic properties. mGluR1 is a group I receptor. Group I mGluRs are predominantly expressed in the postsynaptic somatodendritic regions, especially in brain areas highly responsive to psychostimulants. mGluR1 is a pivotal regulator of glutamatergic neurotransmission which is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions.

Group I mGluRs are coupled exclusively to Gq protein (Gq/11), a heterotrimeric G protein subunit that activates phospholipase C (PLC) and regulates inositol 1,4,5-tris phosphate (IP3) receptors via association with the synaptic scaffolding protein, homer.

mGluRs modulate neuronal excitability and development, synaptic plasticity and neurotransmitter release underlying optimal cognitive function. Activation of mGluR1 facilitates long-term depression of parallel fiber–Purkinje cell synapses critical for cerebellar motor learning.

Anti-mGluR1 antibody

Cat No.Pack SizePriceQty.
20ug£110.00
100ug£220.00
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