Anti-Kat2 antibody
Description
Application Data
Description
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An antibody raised against rat mitochondrial kynurenine aminotransferase 2 (Kat2). Kynurenine aminotransferase (Kat) enzymes convert Kynurenine (KYN) to kynurenic acid (KYNA).
Application Data
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Data Sheet Material Safety Data Sheet (MSDS)Catalogue number crb2005738 Antibody Anti-Kat2 antibody Antigen Peptide KLH conjugated synthetic peptide crb1200947 Protein ID UniProtKB - Q64602 Aliases Kynurenine/alpha-aminoadipate aminotransferase, 2-aminoadipate aminotransferase, Alpha-aminoadipate aminotransferase, Glycine transaminase AADAT, Kynurenine aminotransferase II, KAT/AadAT Cross-Reactivity Rat Host Species Rabbit Antibody Type Polyclonal Concentration 2.0 mg/ml Glycine Target Kat2 Family Class-I pyridoxal-phosphate-dependent aminotransferase family Storage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/thaw cycles. References Herédi et al., (2019). Investigating KYNA production and kynurenergic manipulation on acute mouse brain slice preparations. Brain Res. Bull., 146: 185. doi: 10.1016/j.brainresbull.2018.12.014.
Yoshida et al., (2019). Selective and competitive inhibition of kynurenine aminotransferase 2 by glycyrrhizic acid and its analogues. Sci Rep 9: 10243. doi: 10.1038/s41598-019-46666-y.
Kynurenine aminotransferase (Kat) enzymes convert Kynurenine (KYN) to kynurenic acid (KYNA) as part of the oxidative metabolism of tryptophan. KYNA is an endogenous antagonist of glutamate in the central nervous system. It is most active as an antagonist at receptors sensitive to N-methyl-D-aspartate (NMDA), which regulates neuronal excitability, plasticity, brain development, and behaviour. KYNA is also thought to play a causative role in hypo-glutamatergic conditions such as schizophrenia and a protective role in several neurodegenerative disorders, notably Huntington’s disease. Of the 4 isoforms, Kat2 is the most active. Kat2 is a member of the Class-I pyridoxal-phosphate-dependent aminotransferase family. Kat2 is primarily located in brain tissue, believed to be in the mitochondria; accumulation of KYNA has been associated with schizophrenia. Selective inhibitors of Kat2 are being investigated as therapeutic targets for the management of schizophrenia and cognitive impairment.