Anti-Kat2 antibody 20ug

  • Description

  • Application Data


An antibody raised against rat mitochondrial kynurenine aminotransferase 2 (Kat2). Kynurenine aminotransferase (Kat) enzymes convert Kynurenine (KYN) to kynurenic acid (KYNA).

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Application Data

Catalogue number crb2005738d
Antibody Anti-Kat2 antibody 20ug
Antigen Peptide KLH conjugated synthetic peptide crb1200947
Protein ID UniProtKB - Q64602
Aliases Kynurenine/alpha-aminoadipate aminotransferase, 2-aminoadipate aminotransferase, Alpha-aminoadipate aminotransferase, Glycine transaminase AADAT, Kynurenine aminotransferase II, KAT/AadAT
Cross-Reactivity Rat
Host Species Rabbit
Antibody Type Polyclonal
Concentration 2.0 mg/ml Glycine
Target Kat2
Family Class-I pyridoxal-phosphate-dependent aminotransferase family
Storage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/thaw cycles.

Herédi et al., (2019). Investigating KYNA production and kynurenergic manipulation on acute mouse brain slice preparations. Brain Res. Bull., 146: 185. doi: 10.1016/j.brainresbull.2018.12.014.

Yoshida et al., (2019). Selective and competitive inhibition of kynurenine aminotransferase 2 by glycyrrhizic acid and its analogues. Sci Rep 9: 10243. doi: 10.1038/s41598-019-46666-y.

Material Safety Data Sheet (MSDS)

Kynurenine aminotransferase (Kat) enzymes convert Kynurenine (KYN) to kynurenic acid (KYNA) as part of the oxidative metabolism of tryptophan. KYNA is an endogenous antagonist of glutamate in the central nervous system. It is most active as an antagonist at receptors sensitive to N-methyl-D-aspartate (NMDA), which regulates neuronal excitability, plasticity, brain development, and behaviour. KYNA is also thought to play a causative role in hypo-glutamatergic conditions such as schizophrenia and a protective role in several neurodegenerative disorders, notably Huntington’s disease. Of the 4 isoforms, Kat2 is the most active. Kat2 is a member of the Class-I pyridoxal-phosphate-dependent aminotransferase family. Kat2 is primarily located in brain tissue, believed to be in the mitochondria; accumulation of KYNA has been associated with schizophrenia. Selective inhibitors of Kat2 are being investigated as therapeutic targets for the management of schizophrenia and cognitive impairment.

Anti-Kat2 antibody 20ug

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