Subunit of IL-23, involved in pro-inflammatory pathways
Catalogue number crb2005625 Antibody Anti-IL23A antibody Antigen Peptide KLH conjugated synthetic peptide crb1200832e Protein ID Q9NPF7 human IL23A Aliases Interleukin-23 subunit alpha, Interleukin 23 P19 Subunit, IL-23p19 Cross-Reactivity Human Target Protein Species Human Host Species Rabbit Antibody Type Polyclonal Concentration 0.5mg/ml Target Interleukin-23 subunit alpha Storage Stabilisers The product should be stored at -20°C for short term storage and long term storage. Avoid repeated freeze/ thaw cycles. Storage The product should be stored at -20°C for short term storage and long term storage. Avoid repeated freeze/ thaw cycles. References
Lim et al., (2020). Inflammatory and mitogenic signals drive interleukin 23 subunit alpha (IL23A) secretion independent of IL12B in intestinal epithelial cells. J Biol Chem. 295(19): 6387. PMID: 32209656
Together with IL12B, IL23A forms part of the heterodimeric cytokine IL-23 which functions in innate and adaptive immunity. IL-23 is a member of the IL-12 family of cytokines that includes IL-12, IL-35, IL-27, and IL-39. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R and activates the Jak-Stat signaling cascade. IL-23 is a key driver of Th17-mediated immune response during infection and inflammation and its over production is involved in several cancers.
IL23A expression is induced by several mechanisms including Tumour necrosis factor (TNF)/NF-κB, mitogen-activated protein kinase (MAPK) signalling and the formation of a transcriptional enhancer complex consisting of proto-oncogene c-Jun (c-Jun), RELA proto-oncogene NF-κB subunit (RelA), RUNX family transcription factor 1 (RUNX1), and RUNX3. Collectively, these proteins induced IL23A secretion.
IL-23 is produced by dendritic cells and macrophages as well as keratinocytes and gastric; intestinal; lung and ovarian epithelial cells.