Recognises IL-11, a multifunctional haematopoietic cytokine implicated in several normal and pathological processes
Western blot analysis of recombinant IL-11.
Lane 1: recombinant IL-11 (1mg)
|Antigen Peptide||KLH conjugated synthetic peptide crb1200323e|
|Protein ID||UniProtKB - P20809|
|Aliases||Interleukin-11, adipogenesis inhibitory factor|
|Target Protein Species||Human|
|Validation||1:500 (WB), 1:1000 (ELISA)|
|Storage Stabilisers||This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/ thaw cycles.|
|Storage||This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/ thaw cycles.|
Tao, L., Huang, G., Wang, R., Pan, Y., He, Z., Chu, X., Song, H. and Chen, L. (2016). Cancer-associated fibroblasts treated with cisplatin facilitates chemoresistance of lung adenocarcinoma through IL-11/IL-11R/STAT3 signaling pathway. Sci Rep, 6(1). PMID: 27922075
Sokolov, A., Kazakov, A., Solovyev, V., Ismailov, R., Uversky, V., Lapteva, Y., Mikhailov, R., Pavlova, E., Terletskaya, I., Ermolina, L., Permyakov, S. and Permyakov, E. (2016). Expression, Purification, and Characterization of Interleukin-11 Orthologues. Molecules, 21(12), 1632. PMID: 27916836
Interleukin-11 (IL-11) is a multifunctional haematopoietic cytokine implicated in several normal and pathological processes. It belongs to the interleukin-6 (IL-6) family of cytokines, which affect intracellular signalling pathways via interaction with the ubiquitously expressed signal-transducing receptor, gp130 and a non-signalling cytokine-specific receptor.
IL-11 is expressed in hepatocytes, B cells, macrophages and osteoclasts and it activates JAK/STAT and MAPK signalling pathways, exerting in some cases drastically different physiological effects. IL-11 favours oncogenesis in numerous overlapping cancer types such as gastrointestinal cancers, breast cancer and osteosarcoma. IL-11 has growth factor activity, immunological activity and plays a role in female fertility control. IL-11 is under investigation for treatment of rheumatoid arthritis, Crohn’s disease, and other inflammatory conditions.