Anti-Histone H2B antibody
Description
Application Data
Description
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Recognises histone H2B, one of the four core histone proteins
Application Data
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| Catalogue number | crb2005165 |
|---|---|
| Antibody | Anti-Histone H2B antibody |
| Antigen Peptide | KLH conjugated synthetic peptide crb1200311e |
| Protein ID | UniProtKB - P62807 |
| Aliases | Histone H2B type 1-C/E/F/G/I |
| Cross-Reactivity | Human, Rabbit, Mouse |
| Target Protein Species | Human, Rabbit, Mouse |
| Host Species | Rabbit |
| Antibody Type | Polyclonal |
| Concentration | 1mg/ml |
| Validation | 1:1000 (WB), 1:1000 (ELISA), |
| Target | Histone H2B |
| Storage Stabilisers | This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/ thaw cycles. |
| Family | Histones |
| Disease Area | Histones |
| Specificity | Protein |
| Storage | This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/ thaw cycles. |
| References | Cole et al., (2014). Histone H2B monoubiquitination: roles to play in human malignancy. Endoc-Related Cancer. 22(1), T19-T33. PMID: 24891457
Khan et al., (2017). Nitration of H2B histone elicits an immune response in experimental animals. Autoimmunity. 50(4), 232-240. PMID: 28737980
Mao et al., (2016). A basic domain in the histone H2B N-terminal tail is important for nucleosome assembly by FACT. Nucleic Acids Res. 44(19), 9142–9152. PMID: 27369377 |
Antibody which recognises human histone H2B. H2B is one of the four core histone proteins which make up the protein core of the nucleosome around which DNA is wound to form the basic unit of chromatin. H2B, like other histone proteins is highly conserved across species with even distantly related species having high levels of sequence homology. Post translational modifications of histones such as H2B by acetylation, phosphorylation and ubiquitination can affect the organisation of the chromatin and gene transcription. There are 16 isoforms of H2B in humans, 13 that are expressed in somatic cells, and 3 that are testis-specific.