Antibody raised against Grb14; an adapter protein used to modulate coupling of cell surface receptor kinases with specific signalling pathways. Regulates PDPK1 membrane translocation in response to insulin, promoting transduction of insulin signals.
Catalogue number crb2005655 Antibody Anti-Grb14 antibody Antigen Peptide KLH conjugated synthetic peptide crb1200864e Protein ID Q14449 Grb14 Aliases Growth factor receptor-bound protein 14, GRB14 adapter protein Cross-Reactivity Human Host Species Rabbit Antibody Type Polyclonal Concentration 2mg/ml Glycine (R1G) Target Grb14
Growth factor receptor-bound protein 14 (Grb14) is the final described member of the Grb7 family of proteins, containing Grb7, Grb10 and Grb14. The Grb7 family all share a series of domains involved in protein-protein and protein-lipid interactions.
Under ligand induction, Grb14 binds to various receptor tyrosine kinases (RTKs), this interaction relies on the specific SH2 and PIR domains. These domains are likely a determinant of the specificity of Grb14 action.
Grb14-RTK interactions are established to be necessary for insulin (IR) receptors; by acting as an inhibitor of IR tyrosine kinase activity, Grb14-RTK complexes are capable of inhibiting insulin effects. Grb14 is a molecular adapter which can specifically bind to activated insulin receptors and inhibit its tyrosine kinase activity. Molecules capable of disrupting this binding have been shown to have potential as insulin sensitising agents.