Antibody raised against GPRC5B, a protein used in G-protein signalling pathways, involved in cell migration through positive regulation of WNT pathway.
Catalogue number crb2005696 Antibody Anti-GPRC5B antibody Antigen Peptide KLH conjugated synthetic peptide crb1200905 Protein ID UniProtKB - Q9NZH0 Aliases G-protein coupled receptor family C group 5 member B, A-69G12.1, Retinoic acid-induced gene 2 protein, RAIG-2 Cross-Reactivity Human, Mouse, Rat Host Species Rabbit Antibody Type Polyclonal Concentration 1.0mg/ml Glycine (R1G), 1.0mg/ml Glycine (R2G), 0.4mg/ml TEA (R2T) Target GPRC5B Family G-protein coupled receptor 3 family Storage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/thaw cycles.
G-Protein Coupled Receptor Family C Group 5 Member B (GPRC5B), also knowns as RAIG2) is a member of the type 3 G protein-coupled receptor superfamily, characterised by the signature 7-transmembrane domain motif. In mammals, GPRC5 receptors have been shown to include four subtypes: GPRC5A (RAIG1), GPRC5B (RAIG2), GPRC5C (RAIG3) and GPRC5D. It is a retinoic acid-inducible G-protein coupled receptor, with the potential to provide evidence for an interaction between retinoid and G-protein signalling pathways.
It is predicted to be involved in cell migration, through positive regulation of the WNT signalling pathway, and in localisation of proteins to the extracellular cell surface membrane. GPRC5B is an all-trans retinoic acid gene, suggested to be involved in neuronal cell differentiation, tubulogenesis and renal regeneration.