Antibody raised against GPRC5B, a protein used in G-protein signalling pathways, involved in cell migration through positive regulation of WNT pathway.
Catalogue number crb2005670 Antibody Anti-GPRC5B antibody Antigen Peptide KLH conjugated synthetic peptide crb1200878e Protein ID Q9NZH0 GPRC5B Aliases G-protein coupled receptor family C group 5 member B, A-69G12.1, Retinoic acid-induced gene 2 protein, RAIG-2 Host Species Rabbit Antibody Type Polyclonal Concentration 2.5mg/ml Glycine (R1G), 2.5mg/ml Glycine (R2G) Target GPRC5B Storage Stabilisers The product should be stored at -20°C for short term storage and long term storage. Avoid repeated freeze/ thaw cycles. Family G-protein coupled receptor 3 family Storage The product should be stored at -20°C for short term storage and long term storage. Avoid repeated freeze/ thaw cycles. References
Chung, H.-J., et al. (2014). G protein-coupled receptor, family C, group 5 (GPRC5B) downregulation in spinal cord neurons is involved in neuropathic pain. Korean Journal of Anesthesiology, 66(3), pp.230–236.
Hirabayashi, Y. and Kim, Y.-J. (2020). Roles of GPRC5 family proteins: Focusing on GPRC5B and lipid-mediated signaling. The Journal of Biochemistry, 167(6).
Robbins, M.J., et al. (2000). Molecular Cloning and Characterization of Two Novel Retinoic Acid-Inducible Orphan G-Protein-Coupled Receptors (GPRC5B and GPRC5C). Genomics, 67(1), pp.8–18.
G-Protein Coupled Receptor Family C Group 5 Member B (GPRC5B), also knowns as RAIG2) is a member of the type 3 G protein-coupled receptor superfamily, characterised by the signature 7-transmembrane domain motif. In mammals, GPRC5 receptors have been shown to include four subtypes: GPRC5A (RAIG1), GPRC5B (RAIG2), GPRC5C (RAIG3) and GPRC5D. It is a retinoic acid-inducible G-protein coupled receptor, with the potential to provide evidence for an interaction between retinoid and G-protein signalling pathways.
It is predicted to be involved in cell migration, through positive regulation of the WNT signalling pathway, and in localisation of proteins to the extracellular cell surface membrane. GPRC5B is an all-trans retinoic acid gene, suggested to be involved in neuronal cell differentiation, tubulogenesis and renal regeneration.