An antibody raised against growth/differentiation factor 15 (GDF15); a ligand that binds to transforming growth factor-beta (TGF) receptors with roles in obesity, cardiovascular disease, and cancer.
Catalogue number crb2005605 Antibody Anti-GDF15 antibody Antigen Peptide KLH conjugated synthetic peptide crb1200809e Protein ID Q99988 Human GDF15 Aliases Growth/differentiation factor 15, GDF15, Macrophage inhibitory cytokine 1, MIC-1, NSAID-activated gene 1 protein, NAG-1, NSAID-regulated gene 1 protein, NRG-1, Placental TGF-beta, Placental bone morphogenetic protein, Prostate differentiation factor Cross-Reactivity Human Target Protein Species Human Host Species Rabbit Antibody Type Polyclonal Concentration 1mg/ml Glycine (R1G), 1mg/ml Glycine (R2G) Validation 1:1000 (ELISA) Target GDF15 Storage Stabilisers The product should be stored at -20°C for short term storage and long term storage. Avoid repeated freeze/ thaw cycles. Storage The product should be stored at -20°C for short term storage and long term storage. Avoid repeated freeze/ thaw cycles. References
Baek et al., (2019). Growth differentiation factor 15 (GDF15): A survival protein with therapeutic potential in metabolic diseases. Pharmacology & therapeutics, 198: 46. PMID: 30790643.
Yang et al., (2017) GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand. Nat. Med., 23(10): 1158. PMID: 28846099.
GDF15, also called Macrophage Inhibitory Cytokine 1 (MIC-1), is a secreted pleiotropic cytokine expressed by numerous tissues that functions as a disulphide-linked homodimer. Its binding to TGF receptor GFRAL activates the versatile SMAD pathway leading to SMAD transcription factor activation. This has been shown to happen when the cell is injured and an upregulation of GDF15 protein, a stress inducible cytokine. Increased GDF15 levels have been associated with hypoxia, inflammation, oxidative stress, myocardial ischemia, and notably cancer. Raised GDF15 levels are also associated with cardiovascular diseases such as hypertrophy, heart failure, atherosclerosis, endothelial dysfunction, and chronic kidney diseases in diabetes.
Other diseases associated with GDF15 include Hereditary Transthyretin Amyloidosis and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. GDF15 has thus been widely explored as a biomarker for disease prognosis and all-cause mortality.