An antibody raised against the dixin protein; a positive regulator of the Wnt pathway as well as a regulator of cytoskeleton dynamics and neural development.
Catalogue number crb2005700 Antibody Anti-DIXDC1 antibody Antigen Peptide KLH conjugated synthetic peptide crb1200909 Protein ID Q155Q3 - UniProtKB Aliases Dixin, DIXDC1, DIX domain-containing protein 1, Dixdc1, Coiled-coil protein DIX1, Coiled-coil-DIX1, CCD1, KIAA1735 Cross-Reactivity Human, Mouse, Rat Host Species Rabbit Antibody Type Polyclonal Concentration 2mg/ml Glycine (R1G), 2mg/ml Glycine (R2G) Target Dixin Family DIXDC1 family
Dixin activates DVL2 leading to Wnt3a signalling activation. Dixin was found to be an inhibitory regulator of JNK activity via AXIN1 and DVL2. A catalogue of evidence suggests dysregulation of DIXDC1 is involved in the progression and development of a wide variety of cancers including acute myeloid leukaemia (AML), gastric, colon, and retinoblastoma. The role between DIXDC1 regulation of the Wnt pathway cancer cells remains unclear.
Dixin also associates with gamma tubulin at the centrosome, phosphorylation of Dixin has been shown to regulate its function in actin and microtubule cytoskeleton dynamics. Evidence suggests that Dixin is associated with chromosome segregation and cell cycle regulation.
Multiple Dixin isoforms have been identified. Mark1 was identified as key to phosphorylating the various isoforms to regulate dendrite and spine development. Autism spectrum disorders variations in DIXDC1 isoform 1 have been linked to impaired phosphorylation and neuronal morphology.