Anti-Crystallin Alpha B antibody

  • Description

  • Application Data


An antibody raised against Anti-Crystallin Alpha B antibody (CRYAB). CRYAB is a small heat shock protein (chaperone) with roles in aggregate diseases, cancers, cardiomyopathy, and cataracts.

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Application Data

Catalogue number crb2005274
Antibody Anti-Crystallin Alpha B antibody
Antigen Peptide Crystallin Alpha B protein
Aliases Heat Shock Protein Beta-5, Crystallin Alpha B, CRYAB, Alpha-crystallin B chain,, CRYA2, Renal carcinoma antigen NY-REN-27, Rosenthal fiber component
Cross-Reactivity Human
Host Species Rabbit
Antibody Type Polyclonal
Concentration serum
Target Crystallin Alpha B
Family Small heat shock protein (HSP20) family.
Storage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/thaw cycles.

Berry et al., (2001). Alpha-B crystallin gene (CRYAB) mutation causes dominant congenital posterior polar cataract in humans. The American Journal of Human Genetics69(5): 1141. doi: 10.1086/324158.

Zhang et al., (2019). Progression of the role of CRYAB in signaling pathways and cancers. Onco Targets Ther., 12: 4129. PMID: 31239701.

Material Safety Data Sheet (MSDS)

Anti-Crystallin Alpha B antibody (CRYAB) is part of the small heat shock protein (HSP20) family, acting as a chaperone. The holdase activity aims to prevent the aggregation of various proteins in various cellular processes, often to prevent the proteasomal degradation of client proteins. CRYAB aggregates with homologous proteins, including the small heat shock protein HSPB1, to form large heteromeric complexes. CRYAB associates with intermediate filaments as one of the cytoskeletal elements. Not much is known about CRYAB regulation.

CRYAB dysregulation is linked to several aggregate diseases and is a histopathological marker for aggregate-based human disorders. CRYAB is also involved in numerous prostate, lung, and ovarian cancers. In addition, CRYAB is a biomarker for poor prognosis of breast carcinoma progression and metastases to the brain.

Mutations to the CRYAB gene are linked to several myopathies, including cardiomyopathy. Mutated CRYAB results in large granules and aggregates, leading to muscle rigidity, breathing difficulty, congestive heart failure, arrhythmia, and premature death.

CRYAB may contribute to the transparency and refractive index of the lens. In addition, in lens epithelial cells, CRYAB stabilizes the ATP6V1A protein, preventing its degradation by the proteasome. Dysregulation of CRYAB is involved in cataracts.

Anti-Crystallin Alpha B antibody

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