Host protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity.
Catalogue number crb2005616 Antibody Anti-AIP1/ALIX antibody Antigen Peptide KLH conjugated synthetic peptide crb1200823e Protein ID Q8WUM4 Human AIP1/ALIX , Q9WU78 Mouse Aip1/Alix, Q9QZA2 Rat Aip1 Aliases Programmed Cell Death 6 Interacting Protein, PDCD6IP, Apoptosis-Linked Gene 2-Interacting Protein X, ALG-2-interacting protein X, ALIX, ALG-2-interacting protein 1, AIP1, Hp95, E2F1-inducible protein, Eig2 Cross-Reactivity Human, Mouse, Rat Target Protein Species Human, Mouse, Rat Host Species Rabbit Antibody Type Polyclonal Concentration 1mg/ml Glycine (R1G), 1mg/ml Glycine (R2G) Validation 1:1000 (ELISA) Target AIP1/ALIX Storage Stabilisers The product should be stored at -20°C for short term storage and long term storage. Avoid repeated freeze/ thaw cycles. Storage The product should be stored at -20°C for short term storage and long term storage. Avoid repeated freeze/ thaw cycles. References
Missotten et al., (1999). Alix, a novel mouse protein undergoing calcium-dependent interaction with the apoptosis-linked-gene 2 (ALG-2) protein. Cell Death Differ. 6(2):124-9. PMID: 10200558
Sakaguchi et al., (2005). AIP1/Alix Is a Binding Partner of Sendai Virus C Protein and Facilitates Virus Budding. J Virol. 79(14): 8933. PMID: 15994787
Vincent et al., (2003). YPXL/I Is a Protein Interaction Motif Recognized by Aspergillus PalA and Its Human Homologue, AIP1/Alix. Mol Cell Biol. 23(5): 1647. PMID: 12588984
AIP1/Alix is a host protein with anti-interferon capacity which suppresses viral RNA. AIP1/Alix interacts with the C-protein, an accessory protein of Sendai virus (SeV), with the apoptosis-linked-gene 2 (ALG-2) protein and with the Aspergillus class E vacuolar protein sorting protein (Vps) protein Vps32 homologue, a member of a protein complex involved in the early steps of the multivesicular body pathway.
Aip1/Alix antibodies can be used as effective exosomal markers.