Anti-Activin beta-A chain antibody
An antibody raised against activin βA chain; also known as inhibin βA chain, the peptide regulates secretion of FSH by the pituitary gland. It is a positive regulator of hormone secretion from various organs. Also, a role in germ cell development and maturation, erythroid differentiation by activin βA has been proposed.
Catalogue number crb2005602 Antibody Anti-Activin beta-A chain antibody Antigen Peptide KLH conjugated synthetic peptide crb1200803e Protein ID P08476 Human INHBA Aliases Inhibin beta A chain, Inhibin β A chain, INHBA, Activin beta-A chain, Erythroid differentiation protein, EDF Cross-Reactivity Human, Mouse, Rat Host Species Rabbit Antibody Type Polyclonal Concentration 1mg/ml Glycine (R1G), 1mg/ml Glycine (R2G) Validation 1:1000 (ELISA) Target Activin beta-A chain
Activins are part of the transforming growth factor-beta (TGF-β) superfamily, they function as dimers with 2 subunits connected by a disulphide bond. Mammals express 4 subunits – activin βA, activin βB, activin βC and activin βE; βA and βB are identical to the two β subunits of inhibin. Activins are primarily expressed in the gonads, pituitary and placenta and act as signalling proteins while inhibins act as inhibitors. Activins interact with cell surface heteromeric transmembrane receptor complexes. These transmembrane serine/kinase receptors are essential for ligand binding, signalling and phosphorylation. As an endocrine hormone activin’s role was initially characterised in the reproductive system but has since been shown to be more expansive in various development and differentiation pathways. Some of these functions are in cell proliferation, differentiation, apoptosis, metabolism, homeostasis, immune response, and wound repair.
Activins have crucial roles in cell development and progression however, it is also a well-recognised modulator of cancers across the whole body. Activin A mutations have been shown to be linked to fibrodysplasia ossificans progressiva. Dysregulation of activin levels has also been reported in polycystic ovarian syndrome (PCOS) patients while notably high levels were found in women with pre-eclampsia. This antibody could be a useful tool to research further into the roles activin plays in the mammalian system.