Anti-β-Catenin antibody

  • Description

  • Application Data

Description

Recognises β-Catenin a key protein in the Wnt signalling pathway, involved in cancer progression

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Application Data

Catalogue number crb2005237
Antibody Anti-β-Catenin antibody
Antigen Peptide KLH conjugated synthetic peptide crb1200480e
Protein ID UniProtKB - P35222
Aliases Beta-Catenin, Catenin beta-1,CTNNB
Cross-Reactivity Human, rat, mouse, chicken, rhesus macaque
Target Protein Species Human, rat, mouse, chicken, rhesus macaque
Host Species Rabbit
Antibody Type Polyclonal
Concentration 0.4 mg/ml
Validation 1:1000 (ELISA), 1ug/ml (WB)
Target β-Catenin
Storage Stabilisers This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/ thaw cycles.
Disease Area Cancer, DNA Damage, apoptosis, transcription, cell cycle, signal transduction
Specificity Protein
Storage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/ thaw cycles.
References

Shang et al., (2017). The regulation of β-catenin activity and function in cancer: therapeutic opportunities. Oncotarget8(20): 33972–33989. PMID: 28430641

Material Safety Data Sheet (MSDS)

β-Catenin is a multifunctional protein that acts both as a transcriptional co-regulator and an adaptor protein for intracellular adhesion and is a vital component of the Wnt signalling pathway, an evolutionarily conserved pathway crucially involved in embryonic development and tissue homeostasis.

Wnt signalling pathway is the main regulator of β-catenin, when the pathway is not active, β-catenin is kept at a low level by the ubiquitin proteasome system (UPS). Following nuclear translocation via activation of the Wnt signalling pathway, β-catenin is thought to form a transcriptional complex with DNA binding proteins such as TCF/LEF, p300/CBP to help fulfil its role as a transcriptional activator.

Aberrant activation of Wnt signalling results in the accumulation of β-catenin in the nucleus and promotes the transcription of many oncogenes such as c-Myc and CyclinD-1. Indeed, once in the nucleus, β-catenin binds to several nuclear proteins involved in tumour development or progression such as p300/CBP, TATA-box binding protein (TBP), Pontin52, Reptin52, Brg-1, MUC1-C, SOX10, p68/p72, FOXM1, yes-associated protein 1 (YAP1) and FBW1. Over-expression of β-Catenin has been linked to various diseases including colon cancer, hepatocellular carcinoma, pancreatic cancer, lung cancer, skin cancer breast cancer and ovarian cancer.

Anti-β-Catenin antibody

Cat No.Pack SizePriceQty.
20µg£130.00
100µg£250.00
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