Anti-β-Catenin antibody

  • Description

  • Application Data

Description

Recognises β-Catenin a key protein in the Wnt signalling pathway, involved in cancer progression

See full description

Application Data

Catalogue number crb2005237
Disease Area Cancer, DNA Damage, apoptosis, transcription, cell cycle, signal transduction
Antibody Anti-β-Catenin antibody
Antigen Peptide KLH conjugated synthetic peptide crb1200480e
Protein ID UniProtKB - P35222
Aliases Beta-Catenin, Catenin beta-1,CTNNB
Cross-Reactivity Human, rat, mouse, chicken, rhesus macaque
Host Species Rabbit
Antibody Type Polyclonal
Concentration 0.4 mg/ml
Validation 1:1000 (ELISA), 1ug/ml (WB)
Target β-Catenin
Specificity Protein
Citations

Shang et al., (2017). The regulation of β-catenin activity and function in cancer: therapeutic opportunities. Oncotarget8(20): 33972–33989. PMID: 28430641

References

Shang et al., (2017). The regulation of β-catenin activity and function in cancer: therapeutic opportunities. Oncotarget8(20): 33972–33989. PMID: 28430641

Material Safety Data Sheet (MSDS)

β-Catenin is a multifunctional protein that acts both as a transcriptional co-regulator and an adaptor protein for intracellular adhesion and is a vital component of the Wnt signalling pathway, an evolutionarily conserved pathway crucially involved in embryonic development and tissue homeostasis.

Wnt signalling pathway is the main regulator of β-catenin, when the pathway is not active, β-catenin is kept at a low level by the ubiquitin proteasome system (UPS). Following nuclear translocation via activation of the Wnt signalling pathway, β-catenin is thought to form a transcriptional complex with DNA binding proteins such as TCF/LEF, p300/CBP to help fulfil its role as a transcriptional activator.

Aberrant activation of Wnt signalling results in the accumulation of β-catenin in the nucleus and promotes the transcription of many oncogenes such as c-Myc and CyclinD-1. Indeed, once in the nucleus, β-catenin binds to several nuclear proteins involved in tumour development or progression such as p300/CBP, TATA-box binding protein (TBP), Pontin52, Reptin52, Brg-1, MUC1-C, SOX10, p68/p72, FOXM1, yes-associated protein 1 (YAP1) and FBW1. Over-expression of β-Catenin has been linked to various diseases including colon cancer, hepatocellular carcinoma, pancreatic cancer, lung cancer, skin cancer breast cancer and ovarian cancer.

Anti-β-Catenin antibody

Cat No.Pack SizePriceQty.
20ug£110.00
100ug£220.00
Bulk Quote