Sgo1 peptide
Description
Application Data
Description
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Antigenic peptide from mouse Sgo1 ; Sgo1 aids in timely chromosome segregation during mitosis and meiosis by protecting the interaction of cohesin to the centromere.
Application Data
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Material Safety Data Sheet (MSDS)Catalogue number crb1200545 Antibody Sgo1 peptide Antigen Peptide Sgo1 peptide Cross-Reactivity Mouse Target Protein Species Mouse Storage Stabilisers -20°C Disease Area Cancer, DNA damage Storage -20°C References Xu et al., (2009). Structure and function of the PP2A-shugoshin interaction. Mol cell, 35(4): 426. DOI: 10.1016/j.molcel.2009.06.031.
Yin et al., (2008). Shugoshin1 may play important roles in separation of homologous chromosomes and sister chromatids during mouse oocyte meiosis. PloS one, 3(10): e3516. PMID: 18949044.
Timely chromosome segregation during mitosis and meiosis is orchestrated by separase activity cleaving the multi-subunit cohesin complex from the centromere. Sister chromosomes remain attached at the centromere till after meiosis I anaphase due to shugoshins protecting cohesin from separase activity. Recent work shows shugoshin’s role is to interact with PP2A and maintaining cohesin in a dephosphorylated state thus protecting the centromeric RecB protein from separase activity.
In mammals, there are 2 known sugoshins paralogues, Sgo1 and Sgo2, their roles are still being uncovered. Sgo1 appears to play the primary role in cohesin protection during mitosis when most cohesin complexes dissociate from the chromosome arms. Sgo2 plays a more significant role in aiding centromeric cohesion during meiosis. Reduced levels of Sgo1 have been associated with colorectal cancers due to the increased chromosomal instability leading to tumourigenesis. Defective Sgo1 has also been linked to aneuploidy. However, the exact functions of the sugoshins are still being investigated.