DBCO-NHS Ester ≥98%

  • Description

  • Application Data


DBCO-NHS Ester ≥98% is a high purity, activated ester used in the modification of primary amine-containing molecules.

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Application Data

Catalogue number crb7108338
Molecular Weight 653.77
Appearance White to grey amorphous solid
Solubility Water, DMSO, DMF
Chemistry DBCO
Purity ≥99% (HPLC)
cas 1363444-70-5
Storage -20C
Manufacturer Product Number 1491
Material Safety Data Sheet (MSDS)

This DBCO-NHS Ester is Molecular Biology Grade and extremely high purity (≥98%) in order to ensure the highest possible overall product integrity, consistency and performance for the intended research applications. DBCO-NHS Ester (or ADIBO-NHS Ester/DIBAC-NHS Ester), is an amine-reactive building block used for the modification of amine-containing molecules in organic media. It reacts with primary amines (e.g. side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic pH to form covalent bonds. Through copper-free/strain-promoted Click chemistry reactions, it can react with an azide-labelled molecule to produce a stable conjugate (triazole). The short spacer arm adds a small extra mass (228.3 Da) to modified molecules. This product is not recommended for the labelling of proteins or any other biopolymers in aqueous buffers due to poor aqueous solubility. Because DBCOs and azides are absent from biological systems, there is minimal background labelling of cells/lysates.

DBCO-NHS Ester ≥98%

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