DBCO-C6-Acid is a non-activated building block with improved solubility and functionalization efficiency.
Catalogue number crb7108350 Molecular Weight 333.83 Appearance Slightly grey to slightly orange solid Solubility DMSO, DMF, DCM, THF, Chloroform Chemistry Acid Purity >95% (HPLC) cas 1425485-72-8 Storage -20C Manufacturer Product Number A101
DBCO-C6-Acid (or ADIBO/DIBAC) is a non-activated building block commonly used for synthesis of complex molecules for copper-free Click Chemistry reactions. Primary or secondary amines can react with DBCO groups in the presence of activators (e.g. EDC, HATU), forming a stable amide bond. The extended 6-carbon long spacer arm makes this reagent more soluble in commonly used organic solvents (e.g. dichloromethane, chloroform, THF, ethyl acetate) and also greatly improves coupling efficiency and stability of conjugates.